The results showed that in the xenograft tumor model before FANCG gene modification, niraparib tosylate alone had a weak inhibition effect on tumor growth (P > 0.05), while both radiotherapy and combination therapy could effectively inhibit tumor growth in the xenograft model (P < 0.05), and the combination group had a stronger inhibitory effect (P < 0.01). Here, FANCG is linked to neoplasm.