TFAM and Alzheimer disease: Dysfunction in autophagic pathways with mitochondria is common in AD as demonstrated by the hippocampal levels of SIRT1 (F (4, 15) = 18.13; P < 0.0001), mTOR (F (4, 10) = 38.15; P < 0.0001), Beclin1 (F (4, 10) = 34.15; P < 0.0001), LC3B (F (4, 10) = 30.78; P < 0.0001), and TFAM (F (4, 25) = 44.93; P < 0.0001).