MAPT and Alzheimer disease: The prime neuropathological features of the disease in the brain include extracellular deposits of amyloid-β (Aβ) in senile plaques as well as abnormal accumulation of phosphorylated Tau (p-Tau) protein intra-neuronally forming neurofibrillary tangles, Unfortunately, the detailed mechanism underlying AD etiology and pathogenesis has not been yet fully elucidated (Durairajan et al. 2021).