Especially CD20dim CD8+ (and CD4+) memory T cells may represent a pro-inflammatory, pre-TRM-like population, which is more abundant in the blood and CSF, expresses higher levels of brain-homing markers including VLA-4, CCR5, and CCR6, reveals increased myelin specificity, and is reduced by anti-CD20 antibody treatment in MS [61, 85]. Here, CCR5 is linked to myeloid sarcoma.