The Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer (ORIOLE) trial reported improved biochemical progression-free survival in the entire study population and prolonged distant metastasis-free survival in a subgroup in which all prostate-specific membrane antigen positron-emission tomography/computed tomography (PSMA-PET/CT)-positive lesions were treated [5]. This evidence concerns the gene FOLH1 and Familial prostate cancer.