Previous work has identified the ‘cell of origin’ for NSCLC, in particular ADC [BADJ (SPC+/CC10+) and AT2 (SPC+) pulmonary cells] [30, 31], while SCCs, one of the most mutated tumour entities, demonstrated a rather high degree of plasticity and flexibility regarding the required cell of origin [32]. The gene discussed is SFTPC; the disease is neoplasm.