The in vivo genetic clearance of p16Ink4a‐expressing senescent cells in INK‐ATTAC mice has been used as an important tool to study primary mechanism(s) associated with several age‐related conditions, including osteoarthritis and osteoporosis (Baker et al., 2016, 2011; Farr et al., 2017; Jeon et al., 2017; Palmer et al., 2019; Xu et al., 2015, 2018). The gene discussed is CDKN2A; the disease is osteoarthritis.