PDLIM2 and colitis: For example, miR‐214 is overexpressed in the colonic tissues from patients with long‐lasting colitis and CAC, and it reduces PDLIM2 and PTEN expression in human colonocytes, increases the phosphorylation of AKT and activates nuclear factor‐kB, which induces IL‐6 expression and forms a feedback loop that subsequently amplifies the inflammatory response and promotes CRC development [47].