However, when only considering pilocytic astrocytoma, the BRAF V600E mutation was associated with a decreased OS (Log-rank (Mantel-Cox) Test, P<0.0001) (Fig 2E) and PFS (Log-rank (Mantel-Cox) Test, P = 0.0135) (Fig 2F). The gene discussed is BRAF; the disease is pilocytic astrocytoma.