SERPINE1 and liver dysplastic nodule: Although this trial indicated upregulation of CDH1 and PAI-1 mRNAs of urinary pellet in DN, our study showed no significant change in CDH1 and PAI-1 mRNA expression in blood EVs of DN patients compared to DM patients and controls; meanwhile, PAI-1 mRNA was downregulated in DM patients compared to controls.