In addition to the three genes tested in this study, previous findings from our laboratory provide the temporal requirements for another neurodevelopmental disorder risk gene, the synaptic cell adhesion molecule NLGN1/2/3/4/X•nlg-1. Adulthood re-expression of NLGN1/2/3/4/X•nlg-1 can partially reverse impairments in habituation of response probability; however, once neuroligin has functioned to build a circuit capable of normal sensory processing, it is no longer required in adulthood for normal short-term habituation (McDiarmid et al., 2020a,b). This evidence concerns the gene NLGN1 and neurodevelopmental disorder.