Furthermore, the combined analysis of module membership (MM; the degree to which each gene is associated with the module) and the association of specific gene expression with IBD (defined as minus log P value between IBD and HC by t test) revealed that most of these targets were central to module structure, except for KCNT2 and OR2L13, the only two without known roles in inflammation (Fig. 2 E). Here, KCNT2 is linked to inflammatory bowel disease.