31 discrete modules containing highly coexpressed genes were identified (Fig. 1 A), and module preservation analysis confirmed their existence in other inflammatory diseases (ANCA-associated vasculitis [AAV] and systemic lupus erythematosus [SLE]) and different cell types (B cells, neutrophils, and CD4+ and CD8+ T cells; Fig. S1 A). The gene discussed is CD8A; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.