REN and acute kidney injury: AKI occurs in 33% to 50% of rhabdomyolysis patients and is associated with severe renal failure.[6] Acute renal damage with myoglobinuria is the most serious consequence of both traumatic and non-traumatic rhabdomyolysis.[8] Although the precise mechanisms through which rhabdomyolysis impairs renal function are uncertain, experimental studies have suggested possible pathways, which include: Damaged myocytes sequester fluid, resulting in hypovolemia, which activates the renin-angiotensin system, resulting in renal vasoconstriction.