Recently, several biomarkers, including serum GDF15, endostatin, and CXCL16, were increased in CKD patients and they were associated with renal function.[18–20] Therefore, we measured these biomarkers and evaluated the relationship between circulating VEGF-D and blood GDF15, endostatin, and CXCL16. The gene discussed is COL18A1; the disease is chronic kidney disease.