However, new biomarkers for the progression of CKD, including diabetic kidney disease, are needed since serum creatinine and albumin levels can be influenced by various conditions, such as sex, age, inflammation, and nutrient status.[8] According to previous literature, vascular endothelial dysfunction usually precedes a decrease in estimated glomerular filtration rate (eGFR) and development of albuminuria in patients with DM.[8,9] Thus, serum biomarkers associated with endothelial injury may play a crucial role in the early detection of CKD progression in patients with diabetes. This evidence concerns the gene ALB and diabetes mellitus.