ICAM1 and Sepsis: Instead, great health benefits may be realized by correcting the dysregulated immune response which underlies septic shock pathobiology.[11] Endothelial inflammation is a hallmark of sepsis[12–14] and leads to shock and MODS.[15,16] Several cytokines produced by activated endothelial have effects on the endothelia themselves and immune cells that interact with them: IL-6 has a role in angiogenesis.[17–20] Endothelial activation induces expression of ICAM-1, which is involved in sepsis pathogenesis and is markers of end-organ failure, morbidity, and mortality in severe sepsis.[21]