A study has demonstrated that ICAM-1 level in the sepsis and the SIRS groups was significantly higher than that in the control group, and it is also higher in the sepsis group than in the SIRS group.[23] Another study also confirmed that high levels of serum ICAM-1 was associated with the development of MOF.[22] Obregon et al provides an interesting insight that ICAM-1 seem to crucial in the pathogenesis and may potentially work as a complementary tool for the physician in the diagnosis of sepsis.[24]. This evidence concerns the gene ICAM1 and Sepsis.