PLAU and Sepsis: Our study indicated that the level of ICAM-1 and u-Plasminogen Activator was significantly increased in sepsis patients.Bavunoglu et al found that ICAM-1 had a high sensitivity (99%) and specificity (99%) for detecting sepsis.[22] Furthermore, multiple mouse models have shown that ICAM-1 knockout mice with severe forms of sepsis have lower mortality rates.