increase in the thermo-respiratory responses (skin and rectal temperatures, respiration rate) and the resulted dyslipidemia, anemia, systemic inflammation (blood leukocytosis, the increase in the erythrocyte sedimentation rate, in serum concentration of proinflammatory cytokines, heat shock protein-70), significant improvement of the body-weight gain, kidney functions (especially for 4%), blood antioxidant defense system (total antioxidant capacity, the activity of CAT and SOD), protection of animals from oxidative tissue damage and the risk of atherosclerosis. The gene discussed is SOD1; the disease is anemia (phenotype).