Caspase activation was closely related to mitochondrial outer membrane permeability regulated by members of the Bcl-2 family, Zein hydrolysis induces the expression of genes associated with internal (caspase-9) and external (caspase-8) and caspase-3 apoptosis as functional caspases in A549 cells, which causes apoptosis and cancer cell death (Figure 7). Here, CASP8 is linked to cancer.