PNPLA2 and cancer: In recentyears, the role of ATGL in the lipid metabolism of cancercells has also gained attention.63 Cancercells share the hallmark of metabolic reprogramming to sustain theirhigh-energetic demand and proliferation rate, which includes a switchfrom oxidative to glycolytic energy production and aberrant fattyacid metabolism.64 ATGL provides fattyacids from endogenous TAG stores of cancer cells or tumor-surroundingtissues, which could be utilized for membrane synthesis in rapidlyproliferating cells.