PNPLA2 and lung cancer: However, ATGL is consistently less expressedin most investigated cancer specimens65 and silencing of ATGL has a minor effect on fatty acid metabolismand proliferation of cancer cell lines.66 Yet, ectopic overexpression of ATGL induces a glycolytic-to-oxidativemetabolic switch in hepatocarcinoma cells and reduces the proliferationrate of several cancer cell lines.66−68 A very recent studyhas reported that loss of ATGL function causes a pro-Warburg effectin lung cancer cell spheroids but not in two-dimensional (2D) cellcultures.69 These studies indicate a tumor-suppressivefunction of ATGL.