In our results, the tumor positivity rates and SVI detection value for 68Ga-PSMA-PET/CTpost and 68Ga-PSMA-PET/CTpre are slightly higher than those reported in the previous studies [23, 29, 31–33], probably because PSA screening for early detection of PCa has not been widely adopted and therefore more patients already had advanced-stage tumors at the time of PET scans [34]. Here, FOLH1 is linked to posterior cortical atrophy.