MAPT and Alzheimer disease: The pathology in the AD brain includes neuronal and synapse loss, widespread deposits of senile plaques consisting of β-amyloid (Aβ) peptide and neurofibrillary tangles of phosphorylated (p)-tau protein, and activated microglia (Maccioni et al. 2001; Heneka et al. 2015; Scheltens et al. 2016).