Also, recent data suggest that extracellular vesicles released by cells in the tumor microenvironment carry oncogenic microRNAs as well as proteins involved in tumor progression such as CD147, a transmembrane protein involved in metastasis, and CD276/B7-H3, an immune checkpoint protein enabling neuroblastoma cells to evade NK cells [50, 52, 53]. The gene discussed is CD276; the disease is neoplasm.