MEG3 and motor developmental delay due to 14q32.2 paternally expressed gene defect: Methylation analysis at the MEG3 transcriptional start site differentially methylated region on chromosome 14q32 showed complete hypomethylation (Figure 1), which was both different from the normal heterozygous methylation pattern and consistent with a diagnosis of Temple syndrome (31) (OMIM #616222; ref. 32).