TNF and hepatocellular carcinoma: Since hepatoma TSN could induce significant production of cytokines such as TNF-α, IL-6, IL-10, and IL-1β in monocytes and this induction (with the exception of IL-6) could be effectively attenuated by treatment of these cells with the glycolysis inhibitor 2DG (Figure 3H), we hypothesized that some of the autocrine cytokines might also be involved in the regulation of CA12 expression by aerobic glycolysis in monocytes.