CD68 and neoplasm: As shown in Figure 1C and Supplemental Figure 1 (supplemental material available online with this article; https://doi.org/10.1172/JCI153110DS1), CA12 was significantly and specifically upregulated in peritumoral and tumor-infiltrating CD68+ cells compared with their nontumor counterparts, whereas a weak signal or no substantial signal for CA12 was detected for other cellular components in tumor, peritumor, and nontumor liver tissues.