Both immunohistochemical staining and flow cytometry analysis showed that the levels of F4/80+ macrophage infiltration in tumor tissues were significantly reduced in CA12 inhibitor–treated WT mice in comparison with untreated control mice (Figure 7I and Supplemental Figure 7A), and the levels of Ccl8 mRNA expression were significantly reduced in tumor-purified macrophages (Figure 7J). Here, CCL8 is linked to neoplasm.