Consistently, while tumor-associated monocytes (human peripheral blood–derived monocytes transfected with siNC and then treated with HepG2 TSN) could increase tumor volume, lung metastasis, and levels of CD14+ cell infiltration of HepG2 tumors compared with respective controls in NOD/SCID mice in vivo, no such induction effects were observed in mice treated with CA12-depleted tumor-associated monocytes (monocytes transfected with siCA12 before being exposed to TSN) (Supplemental Figure 6B). Here, CD14 is linked to neoplasm.