TNF and neoplasm: As shown in Figure 3I, TNF-α, IL-10, and IL-1β mimicked the effects of TSN in inducing the upregulation of CA12 expression in monocytes, and consistently, anti–TNF-α, anti–IL-10, and anti–IL-1β antibodies attenuated the induction of CA12 in tumor-exposed monocytes (Figure 3J).