Moreover, patients with high CA12 expression exhibited significantly more CD68+ cell infiltration than those with low CA12 expression (Supplemental Figure 2A), and immunofluorescence staining of frozen sections of HCC tissue samples showed that most CA12+ cells in tumor tissues were also positive for the M2 markers CD204 and CD206 (Supplemental Figure 2, B and C). The gene discussed is MRC1; the disease is hepatocellular carcinoma.