Moreover, patients with high CA12 expression exhibited significantly more CD68+ cell infiltration than those with low CA12 expression (Supplemental Figure 2A), and immunofluorescence staining of frozen sections of HCC tissue samples showed that most CA12+ cells in tumor tissues were also positive for the M2 markers CD204 and CD206 (Supplemental Figure 2, B and C). This evidence concerns the gene MSR1 and hepatocellular carcinoma.