RNF146 and Osteopenia: Notably, the inflammatory phenotype observed in Tnks–/–Tnks2fl/fl LysM-Cre mice is different from that in Rnf146fl/fl LysM-Cre mice, which suffer from osteopenia without inflammation (44), demonstrating that tankyrase-mediated ADP-ribosylation of 3BP2 may create a recognition site for other E3 ubiquitin ligases in addition to RNF146.