TNKS and inflammatory bowel disease: Consistent with our in vitro data showing that tyrosine phosphorylation of TLR2 by SRC and SYK that are activated by 3BP2 promotes NF-κB–mediated cytokine production, inflammatory bowel disease and the visceral organ histiocytosis observed in Tnks–/–Tnks2fl/fl LysM-Cre mice were abrogated in Tnks–/–Tnks2fl/fl Sh3bp2fl/fl LysM-Cre mice (Figure 9A).