NFKB1 and amyotrophic lateral sclerosis: Phosphorylation of NF-κB (p-NF-κB), an established intracellular effector downstream of IL-18 signaling, was similarly higher in the ALS LCLs with canonical IL18RAP 3′UTR and also significantly reduced in control and ALS LCLs, harboring IL18RAP variants (Fig. 3c,d).