PARP1 and neoplasm: For instance, important regulators involved in tumor development such as the poly (ADP-ribose) polymerase 1 PARP1, the MAP kinase MAP3K5, the chromatin-remodeling ATPase INO80, the histone methyltransferase KMT2A, the E3 ubiquitin-protein ligase NEDD4, the Rho-associated protein kinase ROCK2, the telomere protection protein POT1, the transcriptional regulators SMAD1, and SMAD2 are presumably regulated solely by RB and not by DREAM (Table 1).