Representative examples are TIMELESS, the topoisomerase-binding protein TOPBP1, the Werner syndrome helicase WRN, and several genes from the Fanconi anemia group, e.g., BRIP1/BACH1/FANCJ and FANCC. For some Fanconi genes regulation through CDE/CHR sites and p53-dependent transcriptional repression has been studied in detail [23, 58]. The gene discussed is BRIP1; the disease is Fanconi anemia.