For instance, important regulators involved in tumor development such as the poly (ADP-ribose) polymerase 1 PARP1, the MAP kinase MAP3K5, the chromatin-remodeling ATPase INO80, the histone methyltransferase KMT2A, the E3 ubiquitin-protein ligase NEDD4, the Rho-associated protein kinase ROCK2, the telomere protection protein POT1, the transcriptional regulators SMAD1, and SMAD2 are presumably regulated solely by RB and not by DREAM (Table 1). This evidence concerns the gene RB1 and neoplasm.