TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: Giacomelli and colleagues conducted their screen in isogenic TP53+/+ and TP53−/− human A549 lung adenocarcinoma cells while Boettcher et al. did the same in a K562-TP53wild type CML cell line which expressed a GFP reporter at the CDKN1A locus [33, 45].