PTEN and glioblastoma: Hao demonstrated that, based on the TCGA data, the top six most frequently mutated genes in LGGs were IDH1 (77.25%), TP53 (48.04%), ATRX (39.22%), CIC (22.75%), TTN (17.06%), and PIK3CA (8.43%), while the top six most frequently mutated genes in GBMs (glioblastoma multiforme) were PTEN (34.86%), TTN (32.57%), TP53 (31.55%), EGFR (26.97%), MUC16 (18.07%) and NF1 (12.98%)17.