To guide the genetic models in gliomas, Liu et al. screened out 29 highly overlapping genes with strong prognostic potential by comprehensively reviewing 138 prognostic models33, in which three genes were involved in the ATMERS developed in our study, including LGALS3, BMP2 and KCNB1. Furthermore, aging TME scoring system based on ATMERS was developed by using GSVA method to predict the prognosis and immunotherapeutic response of LGG patients. Here, LGALS3 is linked to central nervous system cancer.