SMURF2 and colorectal carcinoma: In contrast to the above studies that demonstrated the various mechanisms of Smurf2 in CRC using cell lines and/or animal models, one study demonstrated that Smurf2 expression was upregulated in CRC specimens and revealed that high Smurf2 expression was associated with impaired overall survival in microsatellite stable CRC, but not in microsatellite instable CRC18.