To analyze the transduction capacity of AAV2 vectors containing apoA1(WT) and apoA1(4WF) cassettes under control of CMV promoter, Raw 264.7 murine macrophages, rat primary aortic smooth muscle cells (RASMC), human embryonic kidney cells (HEK-293) and rat blood outgrowth endothelial cells (BOEC) were transduced with AAV2-apoA1(WT and 4WF) vectors at multiplicity of infection (MOI) of 105–5 × 105 (1010–3.5 × 1010 VG/ml). The gene discussed is APOA1; the disease is infection.