SMAD4 and pancreatic adenocarcinoma: In contrast, when KRT14 expression (being unfavorable) is high, the opposite tendency is seen for ERBB2 and SMAD4. Similar observations were made for the genes SEZ6L, GRIA1 and SLC12A5 in PAAD, whose impact on survival suggested anti-cancer properties but insufficient data or no differences were observed in IHC specimens.