It is undoubtedly an important gene in esophagus neoplasms since, in addition to opposite regulation by AP-2α/γ, its expression is regulated by ARID3A, ZNF354C: two out of five key transcription factors crucial for carcinogenesis and development of esophageal squamous cell carcinoma70. The gene discussed is ARID3A; the disease is neoplasm of esophagus.