Moreover, the presence of “anti-cancer” next to “pro-tumorigenic” within a single tumor only complicates the final conclusion regarding AP-2 role in that cancer (Table 2; e.g. KRT14 vs GRIA1, SEZ6L, SLC12A5 for AP-2α within PAAD or NTSR1 vs PPEF1 for AP-2γ within LUAD). This evidence concerns the gene PPEF1 and cancer.