NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: NOTCH3 is known to be associated with fatal dominant inherited disorders such as myofibromatosis, cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and lateral meningocele syndrome (OMIM # 600276), as well as different forms of cancer73.