Together our results suggest that ZBP1-dependent necroptosis plays a minor role in the exercise-mediated control of tumor growth, in contrast ZBP1 could be linked to the regulation of the exercise-dependent induction of the innate immunity, as evidenced by a tight correlation to myeloid and NK cell markers in the B16F10 tumors, and the blunted response to wheel running during high-fat feeding. Here, ZBP1 is linked to neoplasm.