Furthermore, we provided new insights into RBMS1-mediated GC metastasis for the first time and explored the molecular mechanism underlying GC metastasis: RBMS1 promotes GC metastasis as a core gene through the autocrine IL-6/JAK2/STAT3 signaling pathway via cytokine transactivation by influencing histone modification in promoter regions. This evidence concerns the gene IL6 and gastric cancer.