In compliance with previous observations, 47/57 (82.5%) osteosarcoma samples and only 8/57 (14%) adjacent non-tumoral samples were tested positive for TRPM8, verifying a differential expression of TRPM8 between osteosarcoma and adjacent non-tumoral tissues (p = 0.001) (Fig. 5C). The gene discussed is TRPM8; the disease is osteosarcoma.