To further elucidate the potential role of mTORC1 and mTORC2 in regulating γδ T cells function, we reconstituted Raptor-f/f-CD2-cre (RapKO) and Rictor-f/f-CD2-cre (RicKO) Vγ4 cells into TCRδ-/- mice respectively and then induced liver fibrosis. The gene discussed is RPTOR; the disease is Hepatic fibrosis.