In addition, there was a significant reduction in hydroxyproline, serum ALT and AST levels, hepatic protein level of α-SMA and mRNA levels of Col1α1, Acta2, TIMP-1 in Vγ4 cells reconstituted mice, while Vγ1 reconstitution also had a slight therapeutic effect (Fig. 1c–g), which indicating TCR-based specific subset of γδ T cells is playing a unique function in liver fibrosis. This evidence concerns the gene ACTA1 and Hepatic fibrosis.