YTHDC1 and lung cancer: However, recent studies have shown that YTHDC1 plays a regulatory role in RNA alternative splicing via recruiting other splicing factors.12,13 Xiao et al. demonstrated that YTHDC1 recruitment of SRSF3 facilitates SRSF3 to perform RNA splicing function.12,13 To verify this, we first knocked down and overexpressed SRSF3 in lung cancer cells and found that SRSF3 promoted RBM4 exon 3 inclusion (Supplementary Fig. S7a).