Since nuclear AURKA plays a vital role in cancer development, we screened six drug libraries containing International drug collection (320), US drug collection (1280), Natural product screening library (120), Epigenetic library (43), Stemness library (303), and Autophagy library (150) in the EGFP-AURKA stable expression system to identify small molecules that could efficiently block AURKA nuclear translocation (Fig. 6a). This evidence concerns the gene AURKA and cancer.