Since BPH/LUTS incidence increases from ~ 50% in men at the age of 50 and reaches approximately 80% in men over the age of 70 [17], we chose to examine the impact of E-cadherin loss in male mice at 24 months of age – corresponding to 75–85 years of age in humans (Figure 1A). This evidence concerns the gene CDH1 and benign prostatic hyperplasia.