Similar to the pattern of E-cadherin immunostaining observed in prostate specimens from BPH patients, mice at 24 months of age displayed cell membrane E-cadherin expression in the epithelial layer of both Control and Cdh1+/- mice, with a diffuse decreased expression in prostate glands of Cdh1+/- mice in all lobes of the prostate (blue arrows, Figure 1D, center panel, Supplementary Figure 1). The gene discussed is CDH1; the disease is benign prostatic hyperplasia.