E-cadherin immunostaining of the epithelial layer in normal adjacent prostate to BPH and BPH glands was uniformly distributed and most intense along the cell membrane, with decreased staining observed in BPH glands as evidenced by a reduction of clearly demarked E-cadherin positive cell borders in BPH glands (Figure 1B) [6]. The gene discussed is CDH1; the disease is benign prostatic hyperplasia.