In the treatment-naïve group, infiltrating CD3+, CD4+, and CD8+ T cells and CD20+ B cell were associated with prolonged survival of GC patients (CD3, HR=0.973 (95% CI 0.962 to 0.984), p<0.001; CD4, HR=0.974 (95% CI 0.956 to 0.992), p=0.005; CD8, HR=0.970 (95% CI 0.956 to 0.983), p<0.001; CD20, HR=0.974 (95% CI 0.958 to 0.989), p=0.001) (online supplemental table S3). This evidence concerns the gene CD8A and gastric cancer.