It is reported that quantity of memory/regulatory T cells (CD45R0+FOXP3+) was significantly lower in the stromal compartment in NAC group than in non-NAC patients, suggesting that chemotherapy can regulate phenotype by tumor tissue compartment.23 Our results showed FOXP3+ T reg cells infiltration in the stromal area were significantly higher in response group and could be a predictive factor for chemotherapy efficacy. Here, FOXP3 is linked to neoplasm.