Furthermore, n=9 neoantigen-specific TCR clonotypes that were shared with tumor tissue were also detected in the blood ex vivo, including n=1 (CD8) and n=6 (CD4) clonotypes for POC1B MUT and n=2 (CD4) clonotypes for MAFF MUT; no WT-specific TCR clonotypes were observed in the blood ex vivo. This evidence concerns the gene CD4 and neoplasm.