MAFF and neoplasm: This included TCRs specific for WT peptides and did not appear to be dependent on WT reactivity—similar numbers of TCRs were observed in the tumor for WT peptides that induced no/low IFN-γ-secretion in an ELISpot (POC1B, NIF3L1 and KEAP1) compared with MAFF, where reactivity was ca. 4 x greater for WT than MUT peptide (figure 3D).