A number of genes are known (eg, KEAP1—Cancer Gene Census gene, tier 1) or strongly indicated (eg, ZNF429—putative cancer gene, tier 2) to have a role in cancer, or have been implicated in cancer using mouse models, according to the Catalog of Somatic Mutations in Cancer database; similarly, mutations in NIF3L1 (c344G>T) and KIAA0408 (c2063G>A) have been previously observed in samples from endometrioid carcinoma and colorectal adenocarcinoma, respectively. The gene discussed is KIAA0408; the disease is cancer.