CNR1 and Parkinson disease: Finally, it is notable that striatal expression of CB1R is dysregulated in both Parkinson’s disease (Zeng et al., 1999; Hurley et al., 2003; Navarrete et al., 2018) and Huntington’s disease (Glass et al., 2000; Van Laere et al., 2010), adult-onset disorders with striosomal abnormalities (Crittenden and Graybiel, 2011), dopamine dysregulation and complex motor and mood dysfunction.