Firstly, even though the patient started to take a nucleot(s)ide analog (NA) for HBV at the time of the first liver resection for HCC and, thereafter, the serum alanine aminotransferase level had remained below the upper limit and the serum HBV DNA level had been suppressed below the detection level (1.3 log IU/ml), HCC recurred 10 years later. This evidence concerns the gene GPT and hepatocellular carcinoma.