These cells were subclustered into six different clusters (Fig. 5a-c and Additional file 1: Fig. S5a-c), and each of them was identified based on the classically expressed genes in ECs [48, 49], including glomerular like ECs (Endo1: SOST+), cancer-related ECs (Endo2: NDUFA4L2+), arterial ECs (Endo3: GJA5+), ACKR1+ ECs (Endo4: ACKR1+), the tip cells (Endo6: CXCR4+), and one undefined cluster (Endo5) (Fig. 5a-c, Additional file 1: Fig. S5a-c and Additional file 6: Table S5). This evidence concerns the gene CXCR4 and cancer.