In addition, we included mutations that are of particular interest because of their segregation with AD in families (p.R880Q, p.G1820S), because they correspond to Tangier or Stargardt disease mutations in respectively ABCA1 (p.A845V) or ABCA4 (p.R1932C) or because they show enrichment in patients versus controls (p.L620P) (Table 1; Fig. 1). The gene discussed is ABCA1; the disease is Alzheimer disease.