SQSTM1 and Parkinson disease: Deletion of Atg7-dependent canonical autophagy contributed to reduction of mDA neurons resulted in progress of Parkinson’s disease (PD) [45] In 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced neurotoxin mouse models, deletion of Atg7-dependent canonical autophagy is associated with accumulation of p62 and ubiquitin marked proteins [45].