It showed that the ROC curve analysis for hsa_cirR_00156, hsa_cirR_000224 and hsa_cirR_000520 [123] were employed for discrimination between HCC patients and the healthy group, the AUC were 0.839, 0.974 and 0.943, respectively, which were higher than that of AFP (AUC = 0.726). Here, AFP is linked to hepatocellular carcinoma.