Finally, nine hub genes were used to construct a prognostic model for patients with HNSCC: risk score = (-0.055) * RNF144A + 0.011 * STC1 + 0.016 * P4HA1 + (-0.042) * FMNL3 + 0.002 * ANO1 + 0.002 * BASP1 + 0.004MME + (-0.106) * PLEKHG2 + 0.003 * DKK1. Here, DKK1 is linked to head and neck squamous cell carcinoma.