Furthermore, in contrast to miR-509-3p, PHLPP2 was found to be significantly downregulated within the colorectal tumor tissues as compared to the adjacent normal (median: − 8.984 (tumor) vs. -5.611 (NAT); N = 25; p < 0.0001) (Fig. 4C). Here, BRD2 is linked to colorectal neoplasm.