BRD2 and neoplasm: MiR-509-3p was found to be frequently overexpressed in the colorectal tumor relative to the paired non-tumor mucosae in nearly 80% (82/103, fold change> 1.5) of cases (median: − 16.5 (tumor) vs. -19.33 (NAT); p < 0.0001) (Fig. 1A).