NLRP3 and neoplasm: For instance, tumor-derived exosomal miR-155 triggers cancer-associated cachexia to enhance tumor progression [23], miR-155 promotes macrophage pyroptosis via regulating NLRP3 inflammasome [24], and miR-155 downregulation can reduce the impaired autophagy in an experimental mouse with pancreatitis and further improve the prognosis of mouse [25].