The chemical binders based on binuclear zinc complexes for diphosphorylated Tau protein have also been reported with low affinity toward monophosphorylated or non-phosphorylated Tau.183 These reporters were used to visualize hyperphosphorylated Tau in hippocampal sections from Alzheimer's disease patients183 and in primary neuron culture from mouse.184. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.