In addition, although the comparison of TMB was not different between the two subsets, MATH analysis revealed that the high-ASF1B group exhibited higher abundances of tumor heterogeneity, which is generally an indicator for poor clinical outcomes in multiple malignances, including HCC (Mroz et al., 2015; Ma et al., 2019; McDonald et al., 2019). Here, ASF1B is linked to hepatocellular carcinoma.